The independent variables considered were age, history of leukoaraiosis, cognitive function, ASP score, SSR, blood uric acid, Hcy, bradykinin, coronary heart disease, hypertension, 24‐h SBPSD, dSBPSD, nSBPSD, SDNN, RMSSD, HF, and LF, which were selected based on differences observed in general data and laboratory indicators. This evidence concerns the gene KNG1 and Abnormal cerebral white matter morphology.