Second, differential gene expression of 91 IDH‐wildtype and 417 IDH‐mutant grade II/III gliomas from TCGA, using a threshold of two‐fold or greater and an adjusted significance P‐value < 0.05, identifying 1297 downregulated genes in IDH‐mutant glioma, including genes related to chemotaxis and immune migration, according to gene ontology (GO) terms [61]. Here, IDH2 is linked to central nervous system cancer.