As such, we postulate that these brief periods of apparent “in-exercise hypoglycemia” might be reflective of something termed exercise-associated rebound hypoglycemia or reactive hypoglycemia, which can occur if carbohydrate feeding is initiated before physical activity, thereby resulting in a transient increase in insulin secretion that can result in hypoglycemia once the exercise begins and glucose disposal rates rise [20,21,22,23]. The gene discussed is INS; the disease is Hypoglycemia.