Additionally, bortezomib and PCC have been found to induce apoptosis in colon cancer cell lines by upregulating TRAIL-induced receptors (TNFRS10 A/B) [39,40], and bortezomib can decrease the growth of cancerous cells by restoring Apaf-1 and increasing the caspase-3 activity [41,42]. Here, APAF1 is linked to malignant colon neoplasm.