Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein, also known as c-FLIP, is a master anti-apoptotic regulator and resistance factor that suppresses tumor necrosis factor-α (TNF-α), Fas-L, and TNF-α-related apoptosis-inducing ligand (TRAIL)-induced apoptosis, as well as apoptosis triggered by chemotherapy agents in various types of cancer [24]. Here, TNF is linked to cancer.