Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2) serves as a lysyl hydroxylase, which has been found to interact with USP15, which promotes CRC invasion and metastasis via activating the AKT/mTOR pathway [120] (Figure 6). Here, PLOD2 is linked to colorectal carcinoma.