EML4 and non-small cell lung carcinoma: Notably in NSCLC, five recurrent chromosomal translocations involving the ALK gene have been reported, resulting in fusion proteins such as echinoderm microtubule-associated protein-like 4 (EML4)–ALK (120 kDa, inv(2)(p21;p23); 13 variants), tyrosine receptor kinase-fused gene (TFG)–ALK (113 kDa, t(2;3)(p23;q21)), kinesin family 5B (KIF5B)–ALK (t(2;10)(p23;p11)), kinesin light chain 1 (KLC1)–ALK (t(2;14)(p23;q32)), and protein tyrosine phosphatase non-receptor type 3 (PTPN3)–ALK (t(2;9)(p23;q31)) [5].