Combined signaling cascades of pERK, MYC, and pSTAT3 were involved in EZH2 expression in nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), classic Hodgkin lymphoma (cHL), T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL), and B-cell Lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphomas and classic Hodgkin lymphomas (BCLu-DLBCL/cHL) [6]. This evidence concerns the gene EZH2 and diffuse large B-cell lymphoma.