Using an in vivo xenograft model with NORAD-depleted KYSE-150 cells, the authors showed that increased NORAD expression was correlated with ESCC cells’ radio-resistance and that a combination of radiation with antiprogrammed death-1 (PD-1) antibodies was able to decrease tumor growth in NORAD-depleted tumor-bearing mice. This evidence concerns the gene PDCD1 and neoplasm.