CXCR6 and colitis: In addition, it is known that in the pathogenesis of ICI colitis, a prominent role is played by CD8+ T resident memory cells that express high levels of C-X-C chemokine receptor type 6 and 3 (CXCR6/CXCR3), whose ligands (i.e., CXCL9 and CXCL10, respectively) are upregulated by IFN-γ and TNF [83].