FGFR2 and lung carcinoma: At least in the case of lung cancer, a direct TRPA1–FGFR2 interaction has been demonstrated, which results in the inhibition of TRPA1 activity, due to a conformational change in TRPA-1, which in turn induces the ligand-independent activation of FGFR2 and the consequent sustained proliferation and cell invasion [15,16].