LGR5 and colorectal carcinoma: In additional already published CRC cohorts [24,25,26], we also found significant MACC1-LGR5 expression correlations (p = 0.0259, p = 0.0473 and p < 0.0001) with Spearman r = 0.3031, r = 0.5659 and r = 0.7273 values (Figure 9b).