Indeed, there are several biological features supporting the MACC1-LGR5 link, i.e., the involvement of MACC1 and of LGR5 in clathrin-mediated endocytosis [37,38], their localization at the tumor invasion front [39,40], their role in core clock regulation [41,42] and their impact on craniofacial development [43,44]. This evidence concerns the gene MACC1 and neoplasm.