The same long noncoding RNA MACC1-AS1 was also described to promote stemness by antagonizing miR-145 in hepatocellular carcinoma cells [33], via suppressing miR-145-mediated inhibition of the SMAD2/MACC1-AS1 axis in nasopharyngeal carcinoma [34], and promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer [35]. This evidence concerns the gene SMAD2 and nasopharyngeal carcinoma.