IL6 and neoplasm: Thus, various studies have implicated TAMs, via secreted pro-tumoral factors (such as TGFβ, IL-6, IL-1β, IL-4, IL-10, and metallopeptidases), in promoting tumor cell proliferation, epithelial-mesenchymal transformation, and angiogenesis, along with the induction of an immunosuppressive environment by attracting Tregs and MDSC [18,19].