In a human neocortical GBM model engrafted with autologous patient-derived T cells, chemical depletion of myeloid cells reduced IL-10 production by myeloid cells and increased IL-2 and IFNγ production by T cells; in addition, pharmacological IL-10 scavenging increased the frequency of effector GZMB+ T cells [49]. Here, IL2 is linked to glioblastoma.