VEGFA and nonpapillary renal cell carcinoma: The LITESPARK-024 study (NCT05468697) is a randomized phase 1/2 trial comparing the combination of palbociclib with belzutifan versus belzutifan monotherapy in patients with metastatic ccRCC who have been treated with at least two lines of systemic therapy including prior immunotherapy and VEGF-targeted TKIs.