Although there was no significant difference in granzyme B (GZMB) secretion of CD8+ T cells in the KD or OE group, OE of FTSJ1 on tumor cells directly suppressed perforin secretion function of T cells (p = 0.0047) while KD FTSJ1 on tumor cells significantly reversed the tendency (p = 0.0149) (Figure 5F–H). This evidence concerns the gene PRF1 and neoplasm.