Jacobs et al., analyzed the BRAF and NRAS genotype by pyrosequencing of BRAF exon 15 (inclusive of codons 595 to 601) and NRAS exon 1 (codons 12 and 13) and exon 2 (codons 60 and 61) in 677 metastatic melanoma patients [30]. Here, BRAF is linked to metastatic melanoma.