AKT1 and non-small cell lung carcinoma: Here, we analyzed the expression of the key molecules in AKT/mTOR pathway, showing that the ratio of p-AKT/AKT, p-mTOR/mTOR, p-p70S6K/p70S6K, and p-4E-BP1/4E-BP1 significantly downregulated in PPIP5K2 silencing NSCLC cells, compared with control cells by western blot (Figure 5A).