To determine the extent to which PPIP5K2 stimulates NSCLC cell proliferation and migration via the AKT/mTOR pathway, we applied the AKT activator (SC79) and mTOR activator (MHY1485) to perform rescue experiments in PPIP5K2 knocked-down NSCLC cells. This evidence concerns the gene PPIP5K2 and non-small cell lung carcinoma.