AKT1 and lung cancer: Comparably, we examined the effects of various AKT pathway agonists or antagonists on PPIP5K2-mediated lung cancer metastasis and discovered that a portion of the metastatic potential of PPIP5K2 knockdown cells was recovered by the addition of agonists, whereas the metastatic potential of PPIP5K2 overexpressing cells was completely restored by the addition of inhibitors (Figure 6C,D).