MGMT and glioblastoma: In another retrospective study of 59 patients with GBM, Drabycz et al. used both qualitative and quantitative analyses to determine whether MGMT promoter methylation could be predicted with various MRI sequences [41]; they found that qualitative MRI analysis showed an association between unmethylated MGMT status and ring enhancement, however there was no statistically significant relationship on either FLAIR or T1 post contrast images when a quantitative approach was tested.