CHEK2 and ovarian cancer: Gao et al. [57], investigating the effects of KMP on the cell cycle and extrinsic apoptosis of ovarian cancer cells, demonstrated that KMP induced G2/M cell cycle arrest via checkpoint kinase 2 (CHK2)/cell division cycle 25C (CDC25C)/cyclin-dependent kinase 2 (CDC2) and CHK2/p21/CDC2 in A2780/CP70 human ovarian cancer cells.