In colorectal cancer cells, KMP overcame 5-FU resistance by regulating the microRNA-326–heterogeneous nuclear ribonucleoprotein A1/A2/polypyrimidine tract-binding protein 1–pyruvate kinase M2 (miR-326–hnRNPA1/A2/PTBP1–PKM2) axis [16]. The gene discussed is PKM; the disease is colorectal cancer.