Given the emerging evidence on asprosin and the potential role of PTPRD in regulating cancer cell growth and metastasis, and a recent genome-wide association study (GWAS) meta-analysis indicating that a locus located within PTPRD is associated with endometrial cancer, we investigated its expression in this gynaecological malignancy, which is the fourth most common cancer and the third leading cause of cancer mortality in females worldwide [18,19]. The gene discussed is PTPRD; the disease is endometrial cancer.