PALB2 and breast cancer: Based on the observation that PALB2 PV carriers were fourfold more likely to have a male relative with BC than non-carriers [86], several studies have investigated the presence of PALB2 PVs in MBC cases by candidate single-gene sequencing, and more recently by gene-panel sequencing approaches [25,27,28,29,31,32,85,87,88,89,90,91,92,93,94,95,96].