To identify the impact of S1P on the DLBCL microenvironment, we utilized our previous meta-analysis of 11 different DLBCL gene expression datasets [44,55] in which we had identified subsets of genes either positively or negatively correlated with SPHK1 expression (that we used as a surrogate of S1P signaling). Here, SPHK1 is linked to diffuse large B-cell lymphoma.