CASP3 and cancer: For instance, annonacin and squamocin induce apoptosis in several types of cancer throughout the upregulated expression of caspase 3, 8, and 9, and in turn, the downregulation of Bcl-2 [33,73,74,75], which is in agreement with De Pedro et al. (2013) [76], who observed an increase in caspase 9 activations in LH-treated cell lines.