CD8A and neoplasm: However, when examining the relative localization of CD8+ T cells based on the chemokine expression pattern, the authors calculated the ratio of CD8+ T cells within reach of tumor cells relative to CD8+ T cells in the stroma, and found that tissues with a high CD8+ tumor cell/stroma ratio had higher levels of chemokines CXCL10, CXCL11, and CCL8 [126].