Thus, not only do TME cells, such as CAFs, signal pancreatic cancer cells to secrete CXCL8 for pro-angiogenic effects, but also increase the accumulation of pro-tumorigenic support cells, such as TAMs, highlighting CXCL8’s nefarious role in promoting PDAC tumorigenesis. The gene discussed is CXCL8; the disease is familial pancreatic carcinoma.