PDX1 and neoplasm: For example, Kalbasi et al. identified CCL2 as being produced by orthotopically implanted KrasLSL-G12D/+, Trp53LSL-R172H/+, and Pdx-1 Cre (KPC) PDAC tumors after treatment with radiotherapy to recruit tumor-associated macrophages (TAMs) and promote tumor growth [33].