Additionally, Müller et al. demonstrated that anti-EGFRvIII CAR-NK cells, engineered to express CXCR4, demonstrated increased chemotaxis towards CXCL12/SDF1α-secreting glioblastoma cells, leading to increased survival and tumor regression in a mouse model of glioblastoma [190]. This evidence concerns the gene CXCL12 and neoplasm.