In line with this, we previously showed that pancreatic tumor organoids from cachectic and non-cachectic pancreatic cancer patients expressed variable levels of known cachexia-associated cytokines, including IL-6, TNF-α, IL-8, IL-1α, IL-1β, Mcp-1, and LIF [18]. The gene discussed is TNF; the disease is familial pancreatic carcinoma.