Although COL3A1 expression tended to be increased after exposure to the tumor organoid CM of cachectic patients compared to the control condition (1.4-fold, p = 0.16), no significant differences in SMC COL1A1, COL3A1, or ELN mRNA expression were observed in SMCs exposed to tumor factors from cachectic or non-cachectic patients (Figure 3c). Here, COL3A1 is linked to neoplasm.