Regarding POLR2E rs3787016, CC and C genotypes were significantly correlated with histological subtypes such as ESCC, EAC, SRC and Diffuse, as well as with prognostic variables in the form of PNI, LVI, and PVI, whereas CT variant was associated with CEA. The gene discussed is CEACAM5; the disease is esophageal squamous cell carcinoma.