Taking into account previous evidence, we performed a case-control study analyzing the distribution of HOTAIR rs920778 genotype frequencies in both EC and healthy controls which yielded not significant over-presentation in our EC population in terms of EAC versus ESCC, PNI, LVI, and PVI prognostic variables as opposed to studies implicating HOTAIR with LVI in cancers such as cervical [42,43]. Here, HOTAIR is linked to esophageal squamous cell carcinoma.