POLR2E and esophageal squamous cell carcinoma: SNP rs3787016 (A>G or its complementary T>C, C/T), localized in the fourth intron of the RNA polymerase II subunit E (POLR2E) lncRNA gene, has been implicated with cancer susceptibility either by predisposing for GC [49], breast and cervical cancer [50], or by protecting against ESCC [51] in Chinese populations.