Wang et al. demonstrated that PIM3 increased the proliferation of human pancreatic cancer cells in vitro and in vivo and found that PIM3 is essential for the in vivo vasculogenesis of primary human pancreatic cancers using retroviral vectors PIM3 and a kinase-dead mutant PIM3 (K69M)-infected human pancreatic cancer cell line MiaPaCa-2 and an orthotopic mouse model of pancreatic cancer [37]. The gene discussed is PIM3; the disease is familial pancreatic carcinoma.