PIM3 and neoplasm: Targeting PIM3 by siRNA- inhibited cell proliferation, migration, and invasion while inducing chemo sensitivity and apoptotic cell death. PIM3 overexpression promoted proliferation, migration, and invasion.In vivo targeting PIM3 using siRNA-nano formulations suppressed tumor growth of MDA-MB-231 and MDA-MB-436 tumors in immune-deficient mice