NFKB1 and neoplasm: Wang et al., (2015) showed that the efficacy of PA-MSHA in gastric cancer therapy was achieved by the activation of Nf-kB, which promotes the polarization of M1-like macrophages and increases the production of pro-inflammatory cytokines, including IL12, TNFα, and IFNγ, thereby slowing down tumor progression [31,62].