CDK12 and metastatic neoplasm: Alterations in CDK12, PTEN, and FOXA1 are similarly detected between CSPC and CRPC, whereas those in ATM and RB1 exhibit a similar prevalence between de novo and recurrent metastatic disease, with CDK12 (6% vs. 1%) and FOXA1 (17% vs. 10%) alterations more commonly observed in the de novo metastatic state.