CALR and MPL mutations are typically exclusive to ET and PMF and very rarely occur in PV [10]; however, JAK2 V617F mutation remains the most common driver mutation in PMF, reported in 50–60% of cases, followed by CALR mutations in 25–35% and MPL mutations in 5–10% cases [12,13]. This evidence concerns the gene JAK2 and essential thrombocythemia.