HIF-1α also regulates genes involved in cell survival and metabolism, such as phosphoglycerate kinase (PGK), carbonic anhydrase 9 (CA9), Bcl-2 interacting protein 3 (BNIP3), and glucose transporter 1 (GLUT1), all of which contribute to tumor progression [24]. The gene discussed is HIF1A; the disease is neoplasm.