Increased expression of YY1 was reported in several cancer types, including prostate cancer [29], osteosarcoma [30], breast cancer [31], glioma and meningioma [32], gastrointestinal cancer [33], pancreatic ductal adenocarcinoma [34], melanoma [35], and hepatocellular carcinoma (HCC) [36]. Here, YY1 is linked to osteosarcoma.