Another study clarified the prognostic role of C3, analyzing three gene expression datasets (GSE36895 contained data from 29 ccRCC tissue samples and 23 tumor adjacent tissue samples; GSE53757 from 72 ccRCC samples and 72 tumor-adjacent samples; GSE66272 from 26 ccRCC samples and 26 tumor-adjacent samples) and a cohort of RCC patients in the TCGA database. This evidence concerns the gene C3 and neoplasm.