PTX3 and renal cell carcinoma: At time of diagnosis, the PTX3 serum levels were higher in the patients with RCC compared to healthy controls (p < 0.001) and significantly correlated with a high Fuhrman grade (G3–4 vs. G1–2 p < 0.01), lymph node involvement (N1 vs. N0 p = 0.0008), and visceral metastases (M1 vs. M0 p < 0.001).