MTOR and neuroendocrine neoplasm: Although a variety of treatment options are available for neuroendocrine neoplasms (NENs), amongst others, including systemic chemotherapy, radiation with the radiosensitizing CAP/TEM regime, the mTOR inhibitor everolimus, the multi-kinase inhibitor sunitinib, or immune checkpoint inhibitors, treatment efficacy is limited and the prognosis for this disease is still very poor.