MIR155HG and chronic obstructive pulmonary disease: Conversely, cytokines in chronic obstructive pulmonary disease overexpression of MIR155HG promotes polarization of M1 macrophages and release of proinflammatory, while the knockdown of MIR155HG inhibits polarization of M1 macrophages and increases the polarization of M2 macrophages [69], suggesting a differential role of MIR155HG in chronic inflammation and antitumor immune response.