In the late stages of colorectal cancer (CRC) tumors, TGF-β is highly expressed and acts as a tumor promoter, as the production of several growth factors such as Transforming Growth Factor-α (TGF-α), Fibroblast Growth Factor (FGF) and Epidermal Growth Factor (EGF) is increased. The gene discussed is TGFB1; the disease is neoplasm.