In pancreatic cancer, the AhR ligand kynurenine increased expression of multiple anti-apoptotic proteins, including XIAP and B-cell lymphoma 2 (Bcl-2), while decreasing the pro-apoptotic protein bax, which was abrogated with the addition of the AhR inhibitor CH-223191 [43]. The gene discussed is AHR; the disease is pancreatic neoplasm.