TGFB1 and systemic sclerosis: Increased expression of miR-21 has been confirmed to contribute to the uncontrolled fibrosis in systemic sclerosis (SSc) through the regulation of transforming growth factor β (TGFβ) signaling [129], while the level of miR-29a correlated with both that of miR-21 and the presence of anti-Scl70 antibodies in the serum [132].