Of relevance in this study, we have used α-crystallin without any genetic mutation; however, earlier studies reported that genetic mutation of αA-crystallin (αAc) and αB-crystallin (αBc), i.e., αAc-R116C, αAc-R49C, αAc-G98R, αBc-R120G, and αBc-D140N cause cataracts [7,145,146,147,148,149,150,151,152]; however, the underlying mechanism of cataract formation is unknown. Here, GLYAT is linked to cataract.