While UBASH3B’s role in autoimmunity appears to be limited, UBASH3A has been associated with several autoimmune diseases, particularly in the regulation of T-cell function in the context of type 1 diabetes, systemic lupus erythematosus, celiac disease, rheumatoid arthritis, and vitiligo [4,19,20,25]. This evidence concerns the gene UBASH3A and systemic lupus erythematosus.