The UBASH3A gene downregulates inflammation in the trinitrobenzene sulfonic acid-induced colitis model, where the knockout of either Ubash3a or Ubash3b increases both inflammation and T-cell responses, but the Ubash3a Ubash3b double-knockout mice display a more severe phenotype than either of the single-knockout mice [3]. This evidence concerns the gene UBASH3A and colitis.