IL2 and type 1 diabetes mellitus: Additionally, two type 1 diabetes-associated variants (risk alleles at rs11203203 and rs80054410) in UBASH3A increase UBASH3A expression in primary CD4+ T-cells in humans after T-cell receptor stimulation, which inhibits NF-κB signalling through its effects on the IκB kinase complex, resulting in reduced IL2 gene expression [4].