Moreover, the defect of Cl− and HCO3− secretion by CF submucosal glands contributes to the pH acidification occurring in the ASL, the decrease in liquid secretion, and the increase in protein concentration, functions mediated directly by CFTR anion channels, leading to the loss of activity of antimicrobial peptides and proteins and mucociliary clearance disruption [63,97,102]. Here, CFTR is linked to cystic fibrosis.