IL1B and chronic obstructive pulmonary disease: Numerous other mediators could be implicated in COPD hypersecretion and goblet cell hyperplasia, namely IL-13, IL-1β, IL-4, CXCL8/IL-8, bacterial endotoxin lipopolysaccharide (LPS), matrix metalloproteinase (MMP)-9, etc., and they are under scrutiny to find effective drugs that are still in the experimental research stage [83,123].