Proteomic analysis of CF sputum samples has established that the CF respiratory tract proteome is distinct from healthy controls, with the differences largely driven by upregulation of neutrophil-related immune and inflammatory responses, such as MPO, IL-8, and calprotectin (calgranulin A and B), as well as differences in a number of pathways, including those related to oxidative stress and actin cytoskeleton rearrangement [261,264,268]. This evidence concerns the gene CXCL8 and cystic fibrosis.