Thus, although we did not detect a significant MA-induced reduction in the GluN1 expression in male mice (Table 1), the fact that the NMDA pretreatment was able to reverse the MA-induced reversal-learning impairment exhibited by both males and females suggests that our oral MA self-administration procedures reduced the NMDA receptor function in both sexes to induce this cognitive impairment. The gene discussed is GRIN1; the disease is Cognitive impairment.