CDH1 and cystic kidney disease: Figure 1D shows that the cell–cell adhesion molecule E-cadherin was also immunolocalized to the basolateral membrane domains of renal tubules, with the most prominent signal being found in the collecting ducts. In E-cadherin-positive renal cysts (the majority of cysts), the protein was confined to the basolateral plasma membrane domain (Figure 1E,F).