The analysis of the relative (the percentage within total CD3 + CD4+ cells) and absolute (the number of cells per 1 μL of whole peripheral blood) numbers of Th17 cell subsets revealed an increase in the relative and absolute numbers of Th17.1 cells (CXCR3 + CCR4–) in the DM patients (67% and 94% respectively, compared to control patients) (Table 8). The gene discussed is CCR4; the disease is diabetes mellitus.