In addition, the relative and absolute numbers of DP Th17 cells (CXCR3 + CCR4+) were increased in the AIS (by 41 and 50%) and DM (by 81 and 64%) groups, whereas in the SIVD patients, only a relative number of this subset of cells was increased by 67%, compared to control patients. Here, CCR4 is linked to diabetes mellitus.