In this research, we first predicted the target miRNAs that bind to YTHDF1 in breast cancer using RNA22, TargetScan7, and miRDB databases, respectively, and found that all three of these databases predicted a total of 12 potential upstream target miRNAs, with a subsequent correlation analysis finding that only four miRNAs (miR-7856-5p, miR-378g, miR-6874-5p, miR-1182) had a more significant negative correlation with YTHDF1. This evidence concerns the gene YTHDF1 and breast cancer.