Figure 1E depicts the kinds and locations of the YTHDF1 gene mutations. With notable sites for the R404H/C/L mutations, we identified missense mutations in YTHDF1 as the predominant form of genetic changes in breast cancer. The 3D structural map of YTHDF1 is displayed in picture F, and the red-labeled sites in the figure are the R404 sites that are prone to missense mutations in the YTHDF1 protein structure (Figure 1F). The gene discussed is YTHDF1; the disease is breast cancer.