The [4Lys(Ac), 8Lys(Dau=Aoa)]-GnRH-III conjugate did not show any significant tumor growth inhibition effect (7.1% reduction in tumor weight) on this model, while [4Lys(Bu), 8Lys(Dau=Aoa)]-GnRH-III had a significant effect, with 39.4% inhibition, which is higher than the activity level of free Dau (29.7%). Here, GNRH1 is linked to neoplasm.