The present study observed a time-dependent increase in AKT phosphorylation following mitochondrial transplantation, suggesting that endothelial mitochondrial transplantation contributes to melanoma proliferation by enabling AKT-mediated PGC-1α–Nrf2-dependent mitochondrial biogenesis and cellular redox homeostasis, which in turn promotes cell proliferation and inhibit apoptosis. The gene discussed is PPARGC1A; the disease is melanoma.