The study revealed that this natural flavonoid had the capacity to induce G2/M phase cell arrest, autophagy, and apoptosis in GC cell lines through downregulation of the PI3K/AKT/mTOR cascade acting on p-EBP1, p-S6K, and p-eIF4E compared with untreated cells [199]. This evidence concerns the gene AKT1 and gastric cancer.