Here, we discuss (i) the role(s) of TNF/TNFR1/TNFR2 in relation to the organelle abundances and their main antioxidant enzymes, catalase and SOD2, under physiological conditions; (ii) possible mechanisms underpinning the BoDV1-induced changes in both subcellular compartments in Wt mice; and (iii) and the differences in changes in the abundances of both organelles, catalase and SOD2, after BoDV1 infection of TNFTg, TNFR1ko, and TNFR2ko mice compared to Wt mice, with a particular focus on the role(s) of TNFR1/TNFR2. This evidence concerns the gene SOD2 and infection.