BoDV1 infection had little or no effect on mitochondria and peroxisomes, as well as their respective antioxidant enzymes in TNFR1Ko mice, highlighting the altogether protective and pro-survival roles of TNFR2 signaling; hence, the selective blockage of TNFR1 might offer a promising strategy for alleviating BoDV1-mediated CNS pathologies in BD patients. The gene discussed is TNFRSF1B; the disease is Behcet disease.