TSP1 was initially described as a secreted thrombin-sensitive protein component of activated platelets [7], but TSP1 is secreted by several cell types, including endothelial cells [8,9], fibroblasts [10,11], smooth muscle cells [10], pneumocytes [12], macrophages, monocytes [13], and certain tumor cells [14,15,16]. This evidence concerns the gene THBS1 and neoplasm.