LDLR and infection: Lactoferrin significantly inhibited the infection of the four serotypes of DENV and blocked binding between DENV-2 and the cellular membrane by interacting with heparan sulfate (HS), dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN), and low-density lipoprotein receptors (LDLR) [178].