NLRC3 and obesity due to melanocortin 4 receptor deficiency: Furthermore, people with obesity having head and neck cancer are unresponsive to STING-stimulation-based antitumor approaches due to saturated fatty acid (palmitic acid)-mediated NLRC3 activation in their MICs, blocking STING activation and mediated type 1 IFN release (Figure 3) and the associated T-cell-mediated antitumor immune response [219,220].