HMGB1 release during senescence also suppresses E3 ligase tripartite motif protein 30α (TRIM30α, a negative regulator of STING) by binding to its promoter site, which stabilizes STING to induce STAT6 activation in response to genotoxic stress for p21 (cyclin-dependent kinase inhibitor 1A) activation in cancer cells (Figure 2) [194]. The gene discussed is STING1; the disease is cancer.