Future studies are required in this direction as NLRP3 dysfunction serves as a significant driver of MDS, and cGAS/STING signaling in human myeloid cells works upstream of NLRP3 via STING-mediated LCD and initiates K+ efflux-associated pyroptosis (Figure 3) [197,204,205]. The gene discussed is NLRP3; the disease is myelodysplastic syndrome.