Therefore, along with the NLRP3 inflammasome that forms the cGAS/STING/NLRP3 axis in different inflammatory conditions, NLRs negatively regulating the cGLR (cGAS/STING pathway) system have also evolved to protect the host, including humans, from autoinflammatory and autoimmune diseases. This evidence concerns the gene NLRP3 and autoimmune disease.